Fast Scale up Using Microreactors: from Microscale to Production
نویسندگان
چکیده
In this study, the excellent scalability of flow chemistry was shown. Selective formation of mono-bromoketones was chosen as a model reaction. In a full multivariate optimization experiment, 60 different settings for reaction parameters such as temperature and reaction time were screened, requiring only small amounts of chemicals. A mathematical model of the data was obtained and an optimum set of reaction parameters was selected. These settings were applied on a larger scale continuous flow system and led to a production of the target compound phenacyl bromide at a 1.1 g/hr rate.
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تاریخ انتشار 2010